Tesamorlin CAS: 804475-66-9 Unii-mqg94m5eeo Th 9507
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Tesamorelin (INN) (lub npe lag luam Egrifta SV) yog ib daim ntawv hluavtaws ntawm kev loj hlob hormone tso tawm cov tshuaj hormone (GHRH) rau kev kho mob ntawm cov kab mob HIV-associated lipodystrophy thiab yog thawj zaug pom zoo nyob rau hauv 2010. Nws yog tsim thiab tsim los ntawm Theratechnologies, Inc. Canada.Cov tshuaj yog ib tug hluavtaws peptide muaj li ntawm tag nrho cov 44 amino acids ntawm tib neeg GHRH nrog ntxiv ntawm ib tug trans-3-hexenoic acid pawg.
Mechanism ntawm kev ua
Tesamorelin yog N-terminus hloov kho qhov sib xyaw ua ke raws li 44 amino acid sequence ntawm tib neeg GHRH.Daim ntawv hloov kho hluavtaws no muaj txiaj ntsig zoo thiab ruaj khov dua li ntuj peptides.Nws kuj tseem tiv taus ntau dua rau kev sib cais los ntawm dipeptide aminopeptidase dua li tib neeg GHRH.Nws stimulates endogenous GH synthesis thiab tso tawm thiab nce qib ntawm insulin zoo li kev loj hlob zoo (IGF-1).GH tso tawm ces khi rau cov receptors tam sim no ntawm ntau lub cev hauv nruab nrog cev thiab tswj lub cev muaj pes tsawg leeg.Cov kev cai no feem ntau yog los ntawm kev sib xyaw ntawm anabolic thiab lipolysis mechanisms.Txawm li cas los xij, lub luag haujlwm tseem ceeb ntawm tesamoline tau pom los txo cov rog hauv lub cev yog txo qis triglyceride tom qab lipolysis.