Teduglutide CAS: 197922-42-2 Teduglutide (ALX-0600) Revestive

Muaj nuj nqi:
Teduglutide, paub ua lus Askiv li Teduglutide, yog ib qho analogue ntawm glucagon-zoo li peptide 2 (GLP-2), ib qho tshuaj hormones tshwm sim uas txo cov plab hnyuv thiab tso tawm thiab tswj kev loj hlob, kev loj hlob, thiab kho cov hlwb hauv cov hnyuv.Cov tshuaj no ua rau kom muaj pes tsawg leeg ntawm cov hlwb, uas ua rau kom nqus tau nyob rau hauv cov hnyuv me thiab txo qhov mob raws plab.
Kev npaj:
Kev tsim ntawm tsib-ntiv nplhaib qauv muaj feem cuam tshuam rau txoj cai amino acid ntawm Asp los yog Asn, thiab Gly yog qhov yooj yim tshaj plaws tsim lub nplhaib qauv thaum Gly yog ua ke ua ntej Asp vim tsis muaj kev tiv thaiv pab pawg thiab tsis tshua muaj steric hindrance nyob rau sab. saw hlau.Yog li ntawd, nws yog ib qho tseem ceeb uas txoj kev sib txuas ua ke yuav ua rau N-terminal amino acids ntawm Tedulu Chemicalbook peptide tsim ib lub nplhaib tsib lub nplhaib hauv cov txheej txheem ntawm synthesis, uas yuav txo qhov purity.Yog li ntawd, txhawm rau daws qhov teeb meem degradation ntawm Asp-Gly fragment, ib qho kev tiv thaiv tag nrho nrog cov qauv qhia hauv SEQIDNO: 2 yog thawj zaug los ntawm cov khoom sib txuas.Cov khoom tiv thaiv tag nrho yog thawj ~ plaub cov amino acid ntawm N-terminal ntawm tidulutide, nrog rau cov qauv Asp-Gly, thiab tom qab ntawd cov khoom tiv thaiv tag nrho tau huv.Cov purified tag nrho tiv thaiv tawg yog cov khoom-theem ua ke nrog cov fragment peptide resin nrog cov qauv qhia hauv SEQIDNO:12, thiab qhov kawg cleavage tau ua kom tau tidurotide.