Osteogenic Loj hlob Peptide-OGP CAS: 132996-61-3 OGP acetate OSTEOGENIC GROWTH Peptide USP / EP / BP

Somatostatin, tseem hu ua kev loj hlob hormone suppressor hormone (GHIH) los yog ntau lub npe, yog peptide hormone uas tswj cov kab mob endocrine thiab cuam tshuam rau neurotransmission thiab cell proliferation los ntawm kev cuam tshuam nrog G-protein-coupled somatostatin receptors thiab inhibiting kev tso tawm ntau yam. tshuaj hormones.Cov tshuaj hormones thib ob.Somatostatin inhibits insulin thiab glucagon secretion.

Somatostatin tuaj nyob rau hauv ob hom kev ua haujlwm, tsim los ntawm kev hloov pauv ntawm ib qho progenin: ib qho muaj 14 amino acids (pom hauv cov ntaub ntawv ntawm sab xis), thiab lwm yam muaj 28 amino acids.

Hauv cov kab mob vertebrates, muaj rau ntau hom somatostatin, npe hu ua SS1, SS2, SS3, SS4, SS5, thiab SS6.Zebrafish muaj tag nrho rau.Rau qhov sib txawv ntawm cov noob, nrog rau tsib qhov sib txawv somatostatin receptors, muab somatostatin ntau txoj haujlwm.Tib neeg tsuas muaj ib lub noob somatostatin, SST.

digestive system
Somatostatin yog secreted los ntawm delta hlwb ntawm ntau qhov chaw hauv lub plab zom mov, uas yog pyloric sinuses, duodenum, thiab islets.

Somatostatin tso tawm los ntawm pyloric sinuses nkag mus rau hauv lub plawv los ntawm lub portal system thiab ces nkag mus rau hauv lub systemic ncig mus rau qhov chaw ntawm inhibition.Tsis tas li ntawd, somatostatin tso tawm los ntawm δ hlwb tuaj yeem ua haujlwm hauv paracrine.

Nyob rau hauv lub plab, somatostatin ua ncaj qha rau cov kua qaub-tsim parietal hlwb los ntawm G-protein-coupled receptors (uas inhibit adenylate cyclase thiab yog li zoo antagonize histamine stimulation) kom txo tau gastric acid secretion.Somatostatin kuj tseem ua rau cov txheej txheem zom zaub mov tsis zoo los ntawm kev txo qis hauv plab acid los ntawm kev thaiv kev tso tawm ntawm lwm cov tshuaj hormones xws li gastrin thiab histamine.