Tom ntej: Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE Featured duab

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CAS Nr .:170713-75-4

Lub npe:Nociceptin

ceev:1.47 ± 0.1 g / cm3 (Kev kwv yees)

pka:3.19 ± 0.10 (Kev kwv yees)

cia temp.:-20 ° C

Tshuaj formula:C79H129N27O22

daim ntawv:hmoov

Molar loj:1809.04 Nws

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Nonoreceptor/orphenkephalin FQ (N / OFQ) yog 17-amino acid neuropeptide uas yog ib qho endogenous ligand ntawm nonoreceptor (ORL-1).Nociceptive peptide, raws li cov tshuaj antianalgesic zoo, tuaj yeem tiv thaiv cov nyhuv ntawm cov tshuaj tua kab mob.Nws qhov kev ua kom tau txuas rau lub hlwb ua haujlwm xws li kev nkag siab qhov mob thiab kev kawm ntshai.

Cov kab mob caj ces rau prepronociceptin yog nyob ntawm tib neeg Ch8p21.Mob rhiab peptides yog muab los ntawm propain rhiab peptide proteins, nrog rau ob lwm peptides, nocistatin thiab NocII, ob qho tib si uas inhibit N / OFQ receptor muaj nuj nqi.Nociceptin yog thawj piv txwv ntawm kev rov qab tshuaj pharmacology;NOP receptor tau tshawb pom ua ntej kev tshawb pom ntawm endogenous ligands los ntawm ob pawg sib txawv hauv xyoo 1995.

Hauv kev tshawb fawb tsiaj, N / OFQ-NOP receptor pathway kuj tau pom tias ua si ob qho tib si zoo thiab tsis zoo hauv kev kawm thiab kev nco.Piv txwv li, kev tawg ntawm txoj hauv kev no tau txuas nrog kev hloov pauv hauv kev ntshai kev kawm hauv lub hlwb xws li kev nyuaj siab tom qab (PTSD).Yog li, receptor txoj kev tswj hwm homeostasis cov lus teb rau kev ntshai thiab kev ntxhov siab.Nociceptor tseem tuaj yeem ua lub luag haujlwm inhibitory hauv kev nco, vim qee qhov kev tshawb fawb tau pom tias nws cuam tshuam kev kawm hauv vivo thaum inhibiting kev txhim kho mus sij hawm ntev thiab kev sib kis hauv vitro.