Hot Tags: Semaglutide CAS 910463-68-2 Kub

Taw qhia rau Somaglutide

Somaglutide yog ib tiam tshiab ntawm GLP-1 (glucagon zoo li peptide-1) analog tsim los ntawm Daminol thiab NovoNordisk.Somaglutide yog ib daim ntawv siv ntev ntev uas tsim los ntawm cov qauv ntawm Lilalutide, uas muaj txiaj ntsig zoo rau kev kho mob ntshav qab zib hom 2.Novo Nordisk tau ua tiav 6 PChemicalbookbaseIIIa cov kev tshawb fawb txog kev txhaj tshuaj Somaglutide, thiab xa daim ntawv thov sau npe tshuaj tshiab rau kev txhaj tshuaj Somaglutide txhua lub limtiam rau US Food and Drug Administration (FDA) thaum Lub Kaum Ob Hlis 5, 2016, nrog rau daim ntawv tso cai ua lag luam (MAA) rau European Tshuaj ADministration (EMA).Ntawm qhov tod tes, ib zaug txhua hnub qhov ncauj npaj ntawm Somaglutide yog tam sim no nyob rau hauv kev kho mob theem III.

Kev siv

Somaglutide yog ib daim ntawv siv ntev ntev uas tsim los ntawm cov qauv ntawm liraglutide, uas muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib hom 2.

Kev tshawb fawb

Semeglutide yog ib qho GLP-1 analogue tshiab uas tau txhaj tshuaj subcutaneously ib zaug hauv ib lub lis piam.Somaglutide yog qhov ua haujlwm ntev GLP-1 analog tsim los ntawm Novo Nordisk rau ib zaug / w txhaj tshuaj subcutaneous.Piv nrog liraglutide, Somaglutide muaj cov roj ntsha ntev dua thiab muaj zog hydrophobicity.Txawm li cas los xij, Somaglutide tau hloov kho nrog cov saw luv PEG, thiab nws cov hydrophilicity tau txhim kho zoo heev.Tom qab kev hloov kho PEG, nws tuaj yeem tsis tsuas yog ua ke nrog albumin, npog qhov chaw hydrolysis ntawm DPP-4 enzyme, tab sis kuj txo qis lub raum excretion, ua kom ntev lub neej ib nrab thiab ua tiav cov nyhuv ntawm lub voj voog ntev.Novo Nordisk's Somaglutide hanged DPP-4's Sigliptin, thiab GLP-1's originator, long-acting exenatide (nws yuav tsum tau tsim los sib tw taub hau mus rau lub taub hau nrog Lily's trucity. bullying tau nyob rau hauv lub lag luam ntev).Hauv kev sim, qhov koob tshuaj ntau ntawm Somicalbook txo qis A1C1.6%, thiab qhov hnyav tshaj plaws yog 6 kg.Somaglutide tau siv los tshawb xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm 1.0mg Somaglutide piv nrog 2.0mg Exenatide ib zaug hauv ib lub lis piam hauv 813 cov neeg mob ntshav qab zib hom 2.Lub sijhawm sim yog 56 lub lis piam, thiab cov neeg mob tau noj 1-2 tshuaj tiv thaiv ntshav qab zib hauv qhov ncauj tib lub sijhawm.Thaum Lub Kaum Ob Hlis 2017, FDA tau tso cai pom zoo rau txhua lub lim tiam GLP-1 cov tshuaj hypoglycemic Somaglutide tsim los ntawm NovoNordisk los ua lag luam raws li lub npe lag luam Ozempic.Raws li cov ntaub ntawv soj ntsuam, Ozempic tuaj yeem txo qib HbA1c piv nrog cov placebo, Januvia ntawm Merck, Bydureon ntawm AstraZeneca thiab Lantus ntawm Sanofi.Cov tshuaj kuj pom muaj peev xwm pab cov neeg mob poob phaus.