Clobetasol propionate tuaj yeem kho rau psoriasis? Txhua yam kab mob ntawm daim tawv nqaij?

Clobetasol propionatetuaj yeem kho psoriasis.

Synonyms:

17-propionate; cgp9555; Clobetasol 17-propionate tov, 100ppm; Cloβsol propionate; 21-Chloro-9-fluoro-11b, 17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione; 17-propionate CLOBETASOL 17-PROPIONATE USP; [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 Oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate; Dermovate

Kev siv:

Clobetasol Propionateyog propionate ntsev daim ntawv ntawm clobetasol, tshuaj pleev ib ce hluavtaws corticosteroid nrog anti-inflammatory, anti-pruritic, thiab vasoconstrictive zog.Clobetasol propionate exerts nws cov nyhuv los ntawm kev khi rau cytoplasmic glucocorticoid receptors thiab tom qab ntawd activates glucocorticoid receptor mediated gene qhia.Qhov no ua rau cov synthesis ntawm qee cov tshuaj tiv thaiv kab mob, thaum inhibiting cov synthesis ntawm qee cov kab mob sib kis.Tshwj xeeb, clobetasol propionate zoo nkaus li ua rau phospholipase A2 inhibitory proteins, yog li tswj kev tso tawm ntawm inflammatory precursor arachidonic acid los ntawm daim nyias nyias phospholipids los ntawm phospholipase A2.

Clobetasol propionate yog 17-O-propionate ester ntawm clobetasol thiab nws muab los ntawm clobetasol thiab propionic acid.Ib tug muaj zog corticosteroid, nws yog siv los kho ntau yam kab mob ntawm daim tawv nqaij, xws li exzema thiab psoriasis.
Clobetasol propionate tau patented nyob rau hauv 1968 thiab tuaj mus rau kev kho mob nyob rau hauv 1978. Nws yog muaj nyob rau hauv raws li ib tug tshuaj noj.Clobetasol propionate yog siv rau kev kho mob ntawm ntau yam kab mob ntawm daim tawv nqaij xws li eczema, herpes labialis, psoriasis, thiab lichen sclerosus.Nws kuj tseem siv los kho ntau yam kab mob tsis muaj zog tiv thaiv kab mob, suav nrog alopecia areata, lichen planus (auto immune skin nodules), thiab mycosis fungoides (T-cell tawv nqaij lymphoma).Nws yog siv los ua thawj kab kev kho mob rau ob qho tib si mob thiab mob GVHD ntawm daim tawv nqaij.Clobetasol propionate (Cormax, Temovate, Embeline, Olux) yog ib qho ntawm cov muaj zog tshaj plaws ntawm cov neeg sawv cev tam sim no thiab tau qhia rau kev kho mob luv luv. los yog hyperplastic mob.Nws yog ib qho hluavtaws fluorinated corticosteroid.Nws tuaj yeem ua rau cov lus teb sai dua lossis ntev dua li lwm cov tshuaj corticosteroids.Nws raug pom zoo tias clobetasol muaj qhov siab tshaj plaws ntawm 60 g / lub lis piam ntev dua 14 hnub yam tsis muaj kev cuam tshuam thiab nws yuav tsum tsis txhob siv rau cov menyuam yaus hnub nyoog qis dua 12 xyoos.

Kev daws ntawm betamethasone 21-methanesulfonate (4 g) hauv dimethylformamide (25 ml) tau kho nrog lithium chloride (4 g) thiab sib tov rau hauv chav da dej rau 30 feeb.Dilution nrog dej muab cov khoom crude uas tau recrystallized kom them tau lub npe compound, MP 226 ° C.
Clobetasol feem ntau yog hloov mus rau propionate raws li daim ntawv tseem ceeb los ntawm cov tshuaj tiv thaiv nrog propionic anhydride.