NEUROPEPTIDE FF CAS: 99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF
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NPFF Neuropeptide (FLFQPQRFa) yog ib tug tsiaj txhu aminated neuropeptide Ameslikas cais tawm ntawm lub hlwb bovine thiab tus yam ntxwv raws li ib tug mob-regulating peptide nrog antiopioid kev ua si rau morphine-induced analgesia.
Hauv tib neeg, neuropeptide FF peptide yog encoded los ntawm NPFF noob.Ob lub noob encoding ob qhov sib txawv receptors (NPFF1 thiab NPFF2) thiab ob lub precursors (NPFFA thiab NPFFB) tau cloned nyob rau hauv ntau hom tsiaj.
Neuropeptide FF (NPFF) thiab RFamide ntsig txog peptides tso tawm los ntawm ob lub precursors cuam tshuam nrog ob lub subtypes ntawm G-protein-coupled receptors, NPFF1 thiab NPFF2 subtypes, nrog kev sib raug zoo thiab koom nrog ntau yam kev ua haujlwm ntawm lub cev, xws li kev tswj hwm lub plawv, Kev tswj cov tshuaj hormones, macrophage activation, thermohomeostasis, thiab kev tswj qhov mob.
Kev kho mob ntawm NPFFA precursor ntawm lub hauv paus proteolytic site yuav tsum tau tawm ib peptide uas muaj NPFF, nrog peb ntxiv N-terminal amino acids uas txawv ntawm hom mus rau hom, thiab ib tug peptide uas muaj NPSF (SLAAPQRFa), nws ntev yog nyob ntawm hom.NPFFB tau raug txheeb xyuas tias yog tus thawj coj ntawm RFamide ntsig txog peptide (RFRP, tseem hu ua GnIH ntawm gonadotropin-suppressing hormone), muaj peptides uas muaj LPLRFa thiab peptides sib koom tib lub C-terminal PQRFamide motif li NPFF, xws li NPVF (VPNLPQRFa).
NPFF thiab opioid systems tau pom tias muaj kev cuam tshuam ntawm ntau theem, los ntawm tus cwj pwm tsiaj mus rau receptor molecules.Nociception yog qhov feem ntau kawm txog kev ua haujlwm ntawm lub cev ntawm qhov kev sib cuam tshuam, tab sis qhov khoom plig, txav mus los, noj mov thiab plab hnyuv tau cuam tshuam.Endogenous opioids yuav tsum tau rau cov khoom siv tshuaj tua kab mob ntawm cov leeg txha caj qaum ntawm NPFF, thiab endogenous NPFF peptides tau koom nrog hauv cov txheej txheem ntawm kev ua kom mob siab rau / hyperalgesia vim los ntawm kev kho mob opioid.
NPFF kuj tseem tswj cov lej thiab cov metabolism hauv macrophages hauv cov ntaub so ntswg adipose, uas yog qhov tseem ceeb rau cov ntaub so ntswg adipose.
