Tuam Tshoj Dihexa CAS 1401708-83-5

Kev siv:

DIHEXA (PNB-0408), oligoplase reagent, yog ib qho IV analog ntawm vascular tensionin IV nrog rau qhov ncauj kev ua si thiab ntshav-hlwb barrier permeability.Dihexa high-friendly thiab quab yuam ua ke ua ke hepatocyte kev loj hlob zoo (HGF), ChemicalBookkd tus nqi yog 65PM, thiab txhim kho nws cov haujlwm rau receptor C-MET.Dihexa qhia tau zoo heev los tiv thaiv ejaculation kev ua si thiab txhim kho kev txawj ntse hauv cov qauv tsiaj.Dihexa muaj peev xwm kawm Alzheimer's kab mob.

Dihexa khi nrog siab affinity rau HGF thiab ob qho tib si dihexa thiab nws niam txiv compound Norleucine 1-AngIV induce c-Met phosphorylation nyob rau hauv lub xub ntiag ntawm subthreshold concentrations ntawm HGF thiab augment HGF-nyob ntawm seb lub cell tawg.Ntxiv mus, dihexa thiab Nle1-AngIV induce hippocampal spinogenesis thiab synaptogenesis zoo ib yam li HGF nws tus kheej.Dihexa zoo inhibits HGF dimerization ntawm 1 μM.While dihexa ntawm 1 nM thiab 10 pM ib leeg tsis qhib c-Met, nws tau nce lub peev xwm ntawm HGF ntawm 1.25 thiab 2.5 ng / mL kom qhib c-Met.

Dihexa muaj ib nrab hnub ua haujlwm ntev.Dihexa nthuav tawm kev paub txog kev ua haujlwm.Dihexa thim rov qab scopolamine-dependent spatial kev kawm tsis txaus.Nws txhim kho kev kawm spatial hauv cov nas laus.Dihexa induces spinogenesis hauv kab lis kev cai hippocampal neurons.