Hygromycin CAS: 6379-56-2 Homomycin
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Chemical Properties:
Dawb hmoov.Tsis muaj zog acidic.Dawb soluble hauv dej thiab cawv.Ua los ntawm Streptomyces hygroscopicus.
Kev siv:
Hygromycin A, tshuaj tua kab mob tsis saib xyuas, xaiv tua cov kab mob uas ua rau tus kab mob Lyme.Nws muaj peev xwm kho tau tus kab mob Lyme hauv cov nas tsis cuam tshuam rau microbiome.
Tshuaj (broad-spectrum tshuaj tua kab mob).
Txhais CHEBI: Ib yam khoom ntuj pom muaj nyob hauv hom Streptomyces.
SR 9009 yog ib qho hluavtaws REV-ERB agonist uas tswj cov cwj pwm circadian thiab cov metabolism;muaj peev xwm siv tau rau hauv kev kho mob ntawm kev pw tsaug zog thiab kab mob metabolic.Nws yog cov khoom siv lead ua rau cov chav kawm tshiab ntawm cov tshuaj mob qog noj ntshav cuam tshuam nrog lub cev circadian moos.
SR9009, tseem hu ua Stenabolic, yog cov tshuaj tshawb fawb raws li agonist ntawm REV-ERB.
REV-ERB-α thiab REV-ERB-β, ob lub receptors nuclear, muaj lub luag haujlwm tseem ceeb hauv kev tswj hwm cov lus qhia ntawm cov core moos proteins tsav lub suab hauv kev ua si thiab cov metabolism.
Nyob rau hauv vitro: Ob leeg SR9009 thiab nws cov analog SR9011 tuaj yeem noj tshuaj raws li qhov REV-ERB-dependent repressor kev ua haujlwm soj ntsuam hauv HEK293 hlwb uas qhia txog chimaeric Gal4 DNA binding domain: REV-ERB ligand binding domain α lossis β thiab Gal4-responsive luciferase. .Tsis tas li ntawd, SR9009 tau pom tias tuaj yeem tiv thaiv BMAL1 tus tub txib RNA qhia hauv HepG2 hlwb hauv REV-ERB-α / β-dependent yam.
Hauv vivo: Cov nas raug kho nrog ib koob ntawm SR9009, SR9011 lossis lub tsheb ntawm lub sijhawm circadian 6 (CT6 (6h tom qab teeb rau) tom qab 12 hnub hauv D / D cov xwm txheej uas qhia txog qhov siab tshaj plaws ntawm Rev-erb-α. Cov txiaj ntsig tau pom tias lub tsheb Kev txhaj tshuaj ua rau tsis muaj kev cuam tshuam hauv kev ua haujlwm circadian locomotor, piv txwv li, kev tswj hwm ntawm ib koob tshuaj ntawm SR9009 lossis SR9011 ua rau poob ntawm kev ua haujlwm hauv locomotor thaum lub sijhawm tsaus ntuj. nrog tshem tawm cov tshuaj hauv tsawg dua 24 teev.
