Human Choroinic Gonadotropin HCG CAS: 9002-61-3

Tib neeg chorionic gonadotropin (hCG) yog glycoprotein hormone secreted los ntawm placental endodermal hlwb.Nws lub luag haujlwm tseem ceeb yog txhawm rau txhawb lub corpus luteum, uas yog qhov tsim nyog rau kev tso tawm tsis tu ncua ntawm cov tshuaj estrogen thiab progesterone, txhawm rau txhawb kev tsim cov uterine decidual thiab ua rau cov placenta loj hlob thiab loj hlob.Thaum lub embryo tau cog, cov blastoderm hlwb pib zais hCG, yog li kev xeeb tub tuaj yeem txiav txim siab los ntawm qib hCG hauv cov ntshav lossis zis.

Nws yog tsim los ntawm 244 amino acid residues, nrog ib tug hnyav molecular ntawm 36.7kDa thiab ib tug loj ntawm 7.5 × 3.5 × 3 nm.Nws yog heterodimer nrog tib α subunit li luteinizing hormone (LH), follicle-stimulating hormone (FSH) thiab thyrotropin (TSH), tab sis txawv β subunit.Lub α subunit muaj 92 amino acid residues, thiab β subunit muaj 145 amino acid residues.

hCG synthesis nyob rau hauv cov poj niam yog ho nce tom qab conception, thiab lub xub ntiag ntawm hCG nyob rau hauv plasma thiab tso zis yog ib qho ntawm cov cim ntxov tshaj plaws ntawm cev xeeb tub thiab yog siv rau kev kuaj cev xeeb tub.

(1) Nws muaj kev ua haujlwm ntawm FSH thiab LH los tswj lub neej ntev ntawm kev coj khaub ncaws corpus luteum thiab ua rau kev coj khaub ncaws corpus luteum ua gestational corpus luteum;

(2) Txhawb kev aromatization ntawm androgens rau hauv estrogen, thiab txhawb kev tsim ntawm progesterone;

(3) Inhibiting stimulation nyhuv ntawm cov nroj tsuag lectin ntawm lymphocytes, tib neeg chorionic gonadotropin yuav adsorbed rau saum npoo ntawm trophoblast hlwb, thiaj li kom tsis txhob tawm tsam ntawm embryonic trophoblast hlwb los ntawm leej niam lymphocytes;

(4) LH muaj nuj nqi, ua ntej fetal pituitary secretes LH, nkoos fetal testis secrete testosterone los txhawb txiv neej sib txawv;Kuj tseem tuaj yeem txhawb txoj kev loj hlob ntawm gonadal, txiv neej tuaj yeem txhawb nqa qhov tseem ceeb ntawm cov qe ntshav mesenchymal hlwb, nce qhov tso tawm ntawm txiv neej cov tshuaj hormones (testosterone).Nws yog ib qho tseem ceeb heev rau kev kho mob ntawm cov txiv neej cov neeg mob nrog pituitary ob leeg tsis xws luag, uas yuav tsis tau tsuas yog txhawb gonad txoj kev loj hlob thiab txiv neej cov tshuaj hormones secretion, tab sis kuj txhawb txoj kev loj hlob ntawm lwm yam kev sib deev yam ntxwv.

(5) Nws tuaj yeem khi rau TSH receptor ntawm niam txiv thyroid hlwb thiab txhawb cov thyroid ua haujlwm.