HU-210 CAS Nr .: 112830-95-2

HU-210 yog (--) enantiomer ntawm 11-OH-D 8-THC-DMH, uas muaj yuav luag tag nrho cov dej num ntawm cannabinoids, thaum lub (+) enantiomer, hu ua HU-211, yog inactive li ib tug cannabinoid, tab sis ua es tsis txhob ua tus cannabinoid li NMDA antagonist nrog cov teebmeem neuroprotective.

HU-210 tuaj yeem txhawb kev loj hlob, tab sis tsis sib txawv, ntawm kab lis kev cai embryonic hippocampal neural qia hlwb thiab cov hlwb progenitor los ntawm kev ua kom CB 1 receptor, G i / o protein, thiab ERK signaling sequentially.Qhov kev loj hlob ntawm cov hlab ntsha no kuj qhia tau tias yuav tsum muaj kev tiv thaiv kev ntxhov siab thiab kev tiv thaiv kev nyuaj siab.

Ua ke nrog lwm cov hluavtaws cannabinoids, xws li WIN 55,212-2 thiab JWH-133, HU-210 tiv thaiv kev mob tshwm sim los ntawm Alzheimer's kab mob cuam tshuam nrog beta amyloid, ntxiv rau kev tiv thaiv kev puas hlwb thiab poob ntawm cov cim neuronal.Cov tshuaj tiv thaiv kab mob no yog tshwm sim los ntawm kev ua kom cov cannabinoid receptors, uas tiv thaiv kev ua kom cov kab mob inflammatory microglia.Tsis tas li ntawd, cannabinoids tshem tawm tag nrho cov neurotoxicity cuam tshuam nrog microglial cell activation hauv cov qauv nas.

HU-210 yog ib qho tshuaj tua kab mob muaj zog uas muaj ntau yam cuam tshuam zoo ib yam li THC.

Qhov ncauj LD50 ntawm HU-210 yog 5,000mg / kg hauv nas thiab 14,200mg / kg hauv luav.LDLO (tsawg kawg koob tshuaj tuag) ntawm HU-210 hauv tib neeg yog 143mg / kg.LD50 ntawm caffeine yog kwv yees li 150-200 mg / kg.Delta-8-THC LD50 tsis tau lees paub.Hauv kev tshawb fawb xyoo 1973, cov liab thiab dev tau muab 9,000 mg / kg ntawm Delta-8-THC tsis ua rau tuag taus.