Glucagon CAS: 16941-32-5 Glucagon (1-29) Human HCl Glucagon 1-37

Glucagon, tseem hu ua hyperglycemin thiab glucagon, yog ib txoj hlua ncaj qha polypeptide hormone secreted los ntawm α hlwb ntawm lub txiav txiav, muaj 29 amino acids.Nws cov mis molecular thiab cov txheeb ze molecular hnyav yog C153H225N43O49S = 3482.8.Cov tshuaj no tau raug tsim los hauv kuv lub tebchaws.Dawb zoo crystalline hmoov nyob rau hauv chav tsev kub, odorless, tasteless.Insoluble hauv dej thiab feem ntau cov kuab tshuaj organic, soluble hauv dilute acid thiab dilute lye.Kev npaj feem ntau yog ua los ntawm nws cov hydrochloride, uas yog soluble hauv dej.Nws yog tam sim no paub tias glucagon yuav tsum tswj nws cov molecular kev ncaj ncees thiaj li ua rau nws lub cev ua haujlwm.Cov qauv hyperglycemic yuav zoo ib yam rau tib neeg thiab tsiaj txhu (luav, nyuj, npua, nas, thiab lwm yam), tab sis txawv me ntsis ntawm cov noog.Nws yog ib qho tseem ceeb ntawm cov tshuaj hormones los tswj cov ntshav qab zib.Nws lub luag haujlwm tseem ceeb yog qhib phosphorylase hauv myocardium, txhawb nqa glycogen decomposition thiab muaj cov teebmeem zoo li catecholamin.Yog li ntawd, nws muaj peev xwm ua rau lub plawv muaj zog, ua rau lub plawv dhia, myocardial contractility thiab coronary ntshav khiav.Cardioenhancement tsis yog nrog los ntawm kev ua kom lub plawv dhia, tab sis nce calcium ions rau hauv cardiomyocytes thiab tuaj yeem qhib adenosine cyclase ntawm daim siab cell membrane hauv Chemicalbook, txhawb kev sib txuas ntawm cyclic adenosine phosphate hauv hlwb.Glucagon tau tshaj tawm tias muaj txiaj ntsig zoo hauv qee kis mob plawv.Tsis tas li ntawd, cov ntshav plasma kuj nce mus rau qhov sib txawv ntawm cov ntshav qab zib, kab mob siab, kab mob raum, glucagon qog thiab kev ntxhov siab.Glucagon muaj plaub lub cev kev ua haujlwm ntawm kev txhawb nqa lub siab glycogenolysis, siab glycogenogenesis, lipolysis thiab ketone lub cev tsim.Nws tuaj yeem txhawb nqa cov amino acids nyob rau hauv daim siab hlwb, ua kom cov txheej txheem deamination ntawm cov amino acids hauv daim siab, txo cov concentration ntawm amino acids hauv ntshav, txo cov protein synthesis thiab txhawb lub siab glycogenogenesis.Tsis tas li ntawd, nws tseem tuaj yeem qhib lub peev xwm lipase ntawm daim siab lipid cia cov hlwb, nce kev tso tawm ntawm cov fatty acids dawb, ua kom cov lipoic acid oxidation txheej txheem ntawm daim siab hlwb, thiab ua rau kom lub siab glycoconeogenesis thiab ketone lub cev.Nyob rau tib lub sijhawm, glucagon tuaj yeem cuam tshuam qhov nro thiab peristalsis ntawm lub plab, cov hnyuv thiab cov hnyuv, txo qhov nro ntawm lub gallbladder, inhibit pancreatic exocrine, thiab inhibit qhov nqus dej thiab ntsev los ntawm txoj hnyuv mucosa.Cov koob tshuaj loj ntawm glucagon tuaj yeem ua rau nce cAMP concentration hauv myocardial hlwb, ua kom lub plawv dhia thiab txhim kho myocardial contractility.