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Exendin-4 CAS 141758-74-9 Exenatide Acetate ntsev Exenatide

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  • Hom npe:Exendin-4
  • CAS Nr:.141758-74-9
  • Molecular formula:C184H282N50O60S
  • Molecular Luj:4186.57188 ​​ib
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    Yam ntxwv:

    Hom npe Exenatide English npe Exenatide acetate ntsev
    CAS nr 141758-74-9
    Cov mis mos molecular C184H282N50O60S
    Molecular hnyav 4186.57 000 Nws
    Qhov tseeb loj 4184.03000 Nws
    PSA 1775.0500 Nws
    Cia tej yam kev mob Ntim, khaws cia ntawm -20ºC
    Kev ruaj ntseg Tsis muaj decomposition, tsis paub muaj kev phom sij yog tias siv thiab khaws cia raws li cov lus qhia tshwj xeeb

     

    Kev siv:

    Exenatide yog thawj cov tshuaj nyob rau hauv cov chav kawm tshiab ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib hu ua incretin mimetics, thiab nws tau qhia tias yog kev kho mob ntxiv los txhim kho glycemic tswj hauv cov neeg mob ntshav qab zib hom 2 uas noj metformin, sulfonylurea, lossis ob qho tib si, tab sis tsis muaj. ua tiav kev tswj glycemic txaus.Exenatide yog ib qho kev ua haujlwm zoo ntawm tib neeg incretin Glucagon-zoo li Peptide-1 (GLP-1).GLP-1 yog ib txwm tso tawm los ntawm cov hlwb hauv GI ib puag ncig hauv kev teb rau kev noj zaub mov thiab ua rau nws cov receptor ntawm b-hlwb kom muaj zog cov piam thaj-stimulated insulin secretion.Exenatide yog ib qho agonist ntev ntawm GLP-1 receptor.Nws yog ib tug hluavtaws version ntawm 39-amino acid peptide pom nyob rau hauv cov qaub ncaug secretions ntawm Gila dab lizard.also moderates peak serum glucagon qib thaum lub sij hawm hyperglycemic lub sij hawm tom qab noj mov, tab sis tsis cuam tshuam nrog glucagon tso tawm nyob rau hauv teb rau hypoglycemia.Kev noj tshuaj rau exenatide yog 5 lossis 10 mg ob zaug ib hnub, muab tshuaj rau hauv subcutaneous ib teev ua ntej noj mov thaum sawv ntxov thiab yav tsaus ntuj.Tom qab kev tswj hwm subcutaneous, qhov siab tshaj plaws plasma concentration ntawm exenatide tau mus txog hauv 2.1 h, thiab cov tshuaj plasma pharmacokinetic profile yog koob tshuaj proportional.Cov xwm txheej tsis zoo tshaj plaws uas tau tshaj tawm nrog exenatide muaj xws li xeev siab, ntuav, raws plab, xav tias jittery, kiv taub hau, mob taub hau, thiab dyspepsia.

    Exendin-4 tuaj yeem qhib GLP-1 receptor, tus receptor tuaj yeem nce qib cAMP ntawm pancreatic acinar hlwb hauv intracellular, tab sis nws tsis muaj txiaj ntsig rau VIP receptor.

    Exendin-4 tau siv los ua incretin mimetics rau kev kho mob hauv HepG2 hlwb kom tshem tawm cov kev cuam tshuam ntawm cov khoom siv.Nws kuj tau siv los ua tus r (GLP-1R) agonist kom tsis txhob cuam tshuam los ntawm cov khoom pabcuam.

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