CAS: 77472-71-0 2-Oxo-4-Phenyl-1-Pyrrolidineacetic Acid Hydrazide Phenylpiracetam hydrazine

N-formyl derivative 4 tau txais los ntawm reflux ntawm 2 nyob rau hauv formic acid rau 5 teev ntawm ib tug siab yield.Acetic acid N'-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]-hydrazide (5) tau txais los ntawm reflux acetylation ntawm 2 nyob rau hauv acetic acid ntawm ib tug zoo yield.Compound 6 kuj tau los ntawm refluxing 2 nrog 3-(2-bromoacetyl) -4-hydroxy-2 H-chromen-2-ib hauv ethanol.Compound 2 reacts nrog phenyl isothiocyanate nyob rau hauv ethanol ntawm chav tsev kub kom tau 4-phenyl-1-(7-hydroxy-2-oxo-2 H-chromen-4-acetyl -)-thiosemicarbazide (7).
3-{2-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]hydrazono}butanoate (8) ethyl ester (8), 3-{2-[2-( 7-hydroxy-2-oxo-2 H-Chromen-4-yl)-acetyl] Hydrazono} Butanoate (8), yield yog 48% (Option 2).Cov qauv ntawm cov tebchaw 4-8 tau txiav txim siab los ntawm lawv cov ntaub ntawv txheeb xyuas thiab lawv cov IR thiab 1 H-NMR spectra.Kev nqus infrared vim NH, OH thiab C = O ua haujlwm tshwm sim ntawm 3450-3000 thiab 1728-1610cm-1, raws li.Absorption bands txuam nrog kev muaj lwm pab pawg ua haujlwm muaj nyob rau hauv cheeb tsam xav tau.Lub 1 H-NMR spectrum ntawm lub compound qhia tau hais tias ib tug ncov nyob rau hauv lub 8.03-10.58ppm cheeb tsam sib haum mus rau NH thiab OH protons.Sib 4-8