C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-α-aspartylglycylglycyl-

C-terminal peptide (CTX), tseem hu ua carboxy-terminal collagen crosslinking, yog C-terminal peptide ntawm fibrous collagens xws li hom I thiab hom II.Nws yog siv los ua biomarker hauv cov ntshav los ntsuas cov pob txha hloov pauv.Nws tuaj yeem siv los pab cov kws kho mob txiav txim siab tus neeg mob cov lus teb rau kev kho mob tsis yog phais, nrog rau ntsuas tus neeg mob qhov kev pheej hmoo ntawm cov teeb meem thaum kho tom qab kev phais.[1] Kev sim rau CTX cov cim, hu ua Serum CrossLaps, yog qhov tshwj xeeb rau cov pob txha resorption dua li lwm yam kev sim tam sim no

Nyob rau xyoo 2000s thaum ntxov, kev sib txuas tau muab sau tseg ntawm kev siv bisphosphonate thiab kev puas tsuaj rau pob txha.Qhov hnyav inhibition ntawm osteoclast muaj nuj nqi los ntawm kev kho bisphosphonate tuaj yeem ua rau muaj kev cuam tshuam ntawm cov pob txha ib txwm muaj, ua rau muaj qhov mob tsis zoo tom qab raug mob (xws li kev phais hniav), thiab txawm tias tsis kho pob txha raug mob.Vim tias bisphosphonate nyiam tso rau hauv cov pob txha nrog kev hloov pauv siab, qib bisphosphonate hauv lub puab tsaig yuav raug xaiv kom siab.

Nrog rau kev nthuav dav ntawm kev cog hniav, ntau tus neeg mob kho hniav tau txais kev kho mob nrog cov pob txha kho hauv lub qhov ncauj, xws li kev cog hniav thiab cov pob txha grafts.Txhawm rau ntsuas qhov kev pheej hmoo ntawm osteonecrosis hauv cov neeg mob noj bisphosphonates, Rosen tau qhia CTX biomarker hauv xyoo 2000.