2-Fluoroamphetamine CAS NO: 1716-60-5
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Kev siv
2-fluamphetamine (2-FA) yog ib qho tshuaj stimulant nyob rau hauv tsev neeg amphetamine thiab tau muag raws li ib qho tshuaj tshwj xeeb.2-Fluoroamphetamine txawv ntawm 3- thiab 4-fluoroamphetamine nyob rau hauv txoj hauj lwm ntawm fluorine atoms ntawm lub nplhaib aromatic, ua rau lawv positional isomers ntawm ib leeg.Hloov cov hydrogen atoms nrog fluorine atoms nyob rau hauv qee cov tebchaw los pab txhawb kev nkag mus ntawm cov hlab ntsha-hlwb barrier, raws li xav tau rau cov tshuaj hauv nruab nrab paj hlwb, yog ib qho kev coj ua uas tau muab los ntawm qhov kev hloov pauv ntawm cov nyiaj pab no vim qhov sib npaug ntawm lipophilicity.
kws tshuaj
Anorexia koob tshuaj (50% inhibition ntawm kev noj zaub mov tsis pub dhau 2 teev, muab 1 teev ua ntej) = 15 mg / kg (rats; Qhov ncauj).
koob tshuaj analgesic (50% inhibition ntawm tail-clip cov tshuaj tiv thaiv) = 20 mg / kg (nas; ip).
Cov nyhuv ntawm cov ntshav siab: 0.5 mg / kg ( nas; Intravenous) tuaj yeem nce ntshav siab los ntawm 29 millimeters.