Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine
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Hoʻohana
Hoʻohana lāʻau
Hoʻohana pinepine ʻia ʻo Toluene thiazide ma ke ʻano he sedative, hoʻomaha ʻiʻo a me analgesic.Hoʻohana pinepine ʻia e mālama i ka tetanus.He like loa ka Xylazine me nā lāʻau lapaʻau e like me phenothiazine, tricyclic antidepressants a me clonidine.Ma ke ʻano he anesthetic, hoʻohana pinepine ʻia me ka ketamine.Hōʻike ʻia ʻo Xylazine e hoʻemi i ka naʻau o ke kino i ka insulin a me ka lawe ʻana i ka glucose.ʻO Yohimbine he alpha2 adrenergic receptor antagonist i hoʻohana ʻia e hoʻemi i nā pae glucose i nā pae olakino.Hoʻololi ʻo Yohimbine i nā hopena ʻaoʻao o ka toluene thiazide i loko o kahi hoʻonohonoho hoʻomaʻamaʻa inā lawelawe ʻia me ka intravenously ma hope koke o ka lawelawe ʻana i ka toluene thiazide.
pharmacodynamics
ʻO Xylazine kahi mea ikaika alpha 2 adrenergic agonist.Hāʻawi ʻia ka Toluene thiazide a me nā agonists receptor alpha2 adrenergic a puni ke kino i loko o 30-40 mau minuke ke hāʻawi ʻia.Ma muli o kona lipophilicity kiʻekiʻe, hoʻoulu pololei ʻo toluene thiazide i nā mea hoʻokipa α2 waena a me nā mea hoʻokipa αadrenergic peripheral i nā ʻano kikoʻī.Ma ke ʻano he agonist, ʻo toluene thiazide ka hopena i ka hoʻemi ʻana o ka neurotransmission o ka norepinephrine a me ka dopamine i loko o ka ʻōnaehana nūnū waena.Hana ʻia ia ma ka hoʻohālikelike ʻana i ka hoʻopaʻa ʻana o ka norepinephrine i nā autoreceptors ma ka ʻili presynaptic, ka mea e hopena i ka pale ʻana i ka norepinephrine.
Hoʻohana pū ʻo Xylazine ma ke ʻano he mea hoʻokele kaʻa ma ke kāohi ʻana i ka hana transport norepinephrine ma o ka hoʻokūkū hoʻokūkū i ka halihali substrate.No laila, ua hoʻonui nui ka toluene thiazide i ka K m a ʻaʻole i hoʻopilikia i ka V max.Hiki paha kēia ma o ka launa pū ʻana me nā ʻāina i uhi ʻia me nā pae hoʻopaʻa antidepressant.ʻO kahi laʻana, ʻo toluene thiazide a me clonidine ke kāohi i ka lawe ʻana o MIBG (kahi analogue norepinephrine) e nā cell neuroblastoma.Loaʻa i ka Xylazine nā mea like ʻole no ka cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, a me nā mea hoʻokipa opioid.Ua like loa kona kinona me ka phenothiazines, tricyclic antidepressants a me clonidine.