Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

ʻO nā peptides intestinal vasoactive, i ʻike ʻia ʻo vasoactive intestinal peptides a i ʻole VIP, he mau peptide hormones i vasoactive i ka ʻōpū.ʻO VIP kahi peptide e loaʻa ana he 28 amino acid koena no ka glucagon/secretin superfamily a he ligand o Class II G protein-coupled receptors.Hoʻokumu ʻia ka VIP ma nā ʻiʻo vertebrate he nui, me ka ʻōpū, ka pancreas, a me ka suprachiasmatic nucleus o ka hypothalamus o ka lolo.Hoʻoulu ka VIP i ka ʻokiʻoki puʻuwai, hoʻoulu i ka vasodilation, hoʻonui i ka haki ʻana o ka glycogen, hoʻohaʻahaʻa i ke koko arterial a hoʻomaha i nā ʻiʻo maʻemaʻe i loko o ka trachea, ʻōpū a me ka gallbladder.I loko o ke kanaka, ua hoʻopili ʻia nā peptides intestinal vasoactive e nā genes VIP.

ʻO ka hapalua o ke ola (t ½) o VIP i loko o ke koko ma kahi o ʻelua mau minuke.

He hopena ko VIP i nā hui like ʻole:

I loko o ka ʻōnaehana digestive, ʻike ʻia ka VIP e hoʻomaha ai i ka ʻiʻo maʻemaʻe (lower esophageal sphincter, ʻōpū, gallbladder), hoʻoulu i ka huna ʻana o ka wai i loko o ka wai pancreatic a me ka bile, a ke kāohi i ka huna ʻana a me ka absorption o ka waikawa gastric mai ka ʻōpū o ka ʻōpū.ʻO kāna hana i loko o ka ʻōpū ka mea e hoʻoulu nui ai i ka huna ʻana o ka wai a me nā electrolytes, a me ka hoʻomaha ʻana i ka ʻiʻo maʻemaʻe o ka ʻōpū, hoʻomāhuahua i nā kīʻaha koko peripheral, hoʻoulu i ka huna ʻana o ka bicarbonate e ka pancreas a kāohi i ka gastrin-stimulated gastric acid secretion.Hana pū kēia mau hopena e hoʻonui i ka motility.Hoʻoulu pū ia i ka huna ʻana o ka pepsinogen e ke kelepona nui.ʻIke ʻia ʻo VIP he neuropeptide koʻikoʻi i ka wā o ka maʻi ʻōpū ʻeha no ka mea ua hoʻoponopono ʻia ka mast cell a me ka kamaʻilio VIP i ka colitis e like me ka maʻi o Crohn.

Aia i loko o ka puʻuwai a he hopena koʻikoʻi i ka ʻōnaehana cardiovascular.Hoʻokumu ia i ka vasodilation coronary a loaʻa nā hopena inotropic a me ka chronotropic maikaʻi.Ke hoʻomaka nei ka noiʻi ʻana e hoʻoholo inā he hopena maikaʻi kona i ka mālama ʻana i ka naʻau puʻuwai.Hoʻoulu ka VIP i ka lubrication vaginal i nā wahine maʻamau, e pālua i ka nui o ka lubrication i hana ʻia