Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507
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Hoʻohana
ʻO Tesamorelin (INN) (inoa kālepa ʻo Egrifta SV) he ʻano synthetic o ka hormone e hoʻokuʻu ana i ka hormone ulu (GHRH) no ka mālama ʻana i ka lipodystrophy pili i ka maʻi HIV a ua ʻae ʻia i ka makahiki 2010. Ua hana ʻia a hoʻomohala ʻia e Theratechnologies, Inc. Canada.ʻO ka lāʻau lapaʻau he peptide synthetic i haku ʻia me nā 44 amino acids o ke kanaka GHRH me ka hoʻohui o kahi hui trans-3-hexenoic acid.
Mechanism o ka hana
ʻO Tesamorelin kahi pūhui N-terminus i hoʻololi ʻia e pili ana i ka 44 amino acid sequence o GHRH kanaka.ʻOi aku ka maikaʻi o kēia ʻano synthetic i hoʻololi ʻia ma mua o nā peptides kūlohelohe.ʻOi aku ka pale ʻana i ka cleavage e dipeptide aminopeptidase ma mua o GHRH kanaka.Hoʻoulu ʻo ia i ka synthesis GH endogenous a hoʻokuʻu a hoʻonui i nā pae o ka insulin-like growth factor (IGF-1).Hoʻopili ka GH i hoʻokuʻu ʻia i nā mea loaʻa i loaʻa ma nā ʻano kino like ʻole a hoʻoponopono i ke ʻano o ke kino.ʻO kēia ka hoʻoponopono ma muli o ka hui pū ʻana o nā mea anabolic a me lipolysis.Eia naʻe, ʻo ka hana nui i loaʻa ai ka tesamoline e hōʻemi i ka momona o ke kino, ʻo ia ka hoʻemi ʻana o nā pae triglyceride ma hope o ka lipolysis.