SARM SR9011 Pharmaceutical Raw Powder no ka hoʻoikaika ʻana i ka hoʻoikaika kino CAS 1379686-30-2
SR9011 Nā kikoʻī wikiwiki
Ka helu helu 1379686-29-9
Nā hua like 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Kōkuhi C23H31ClN4O3S
Kaumaha Molucelar 479.03524
SR9011wehewehe
ʻO SR9011 kahi monomer methacrylate trifunctional e hāʻawi i ka hoʻopili kūikawā i ka metala
nā mea pani.
Manaʻo ʻia ʻo SR9011 no ka hoʻohana ʻana i nā pale i hoʻōla ʻia i ka peroxide, sealants, a me nā plastisols-based PVC.
Hoʻohana ʻia nā pae hoʻohana o 5% a 10% ma ke kaumaha.
ʻO SR9011 kahi REV-ERB synthetic ikaika a kikoʻī.Loaʻa iā ia ka maikaʻi i ka vivo plasma / ʻike lolo.
ʻO nā mea hoʻokipa nuklea REV-ERB-α a me REV-ERB-β he kuleana koʻikoʻi i ka hoʻoponopono ʻana i ka ʻōlelo.
o nā protein clock clock, hoʻokele i nā mele i ka hana a me ka metabolism.Hoʻololi ka hoʻokele o SR9011
ʻO ka hana circadian a me ke ʻano circadian o ka hōʻike gene clock clock i ka hypothalami o nā ʻiole.
ʻO ke ʻano hōʻike circadian o kahi ʻano o nā genes metabolic i loko o ke ake, ʻiʻo iwi a me
Ua hoʻololi ʻia hoʻi ka ʻiʻo adipose, ka hopena i ka hoʻonui ʻana i ka ikehu.Lapaʻau ʻana i ka meaʻai
ʻO nā ʻiole obese me SR9011 i hoʻemi i ka momona ma o ka hōʻemi ʻana i ka momona momona a me ka hoʻomaikaʻi maikaʻi ʻana i ka dyslipidemia a me ka hyperglycaemia.Hōʻike kēia mau hopena i nā ligands REV-ERB synthetic i kuhikuhi ʻia i ka lāʻau lapaʻau
hiki i ka circadian rhythm ke kōkua i ka mālama ʻana i nā maʻi moe a me nā maʻi metabolic.
Pehea e hoʻohana ai iā SR9011?
In vitro: Ua hoʻohana ʻia ʻo SR9011 ma ka 5-10 μM kaʻina in vitro a me nā hoʻokolohua cellular.
In vivo: Ua hoʻohana ʻia ka lawelawe IP o SR9011 ma 100 mg / kg hoʻokahi a ʻelua paha i kēlā me kēia lā no 12-30
nā lā ma nā ʻano ʻiole like ʻole.
Synthesis o SR9009 a me SR9011
| 'ikamu | Hōʻike | Ka hopena |
| Ka nana aku | He pauda ʻala ʻole, aneane keʻokeʻo a keʻokeʻo paha | hala |
| ʻIkepili | ʻO ka manawa mālama o ka piko nui hōʻoia i ka RS | hala |
| Nalo ma ka maloo | ʻAʻole iʻoi aku ma mua o 0.5% | 0.33% |
| Hōʻike (HPLC) | ʻAʻole emi ma lalo o 99.0% | 99.59% |
| Ke koena puhi | ʻAʻole ma mua o 0.1% | hala |
| Metala kaumaha | ʻAʻole iʻoi aku ma mua o 20 ppm | hala |
Puke a me ka lawe ʻana
