Osteogenic Growth Peptide-OGP CAS:132996-61-3 OGP acetate OSTEOGENIC GROWTH PEPTIDE USP/EP/BP

ʻO Somatostatin, ka mea i kapa ʻia ʻo growth hormone suppressor hormone (GHIH) a i ʻole kekahi mau inoa ʻē aʻe, he hormone peptide e hoʻoponopono i ka ʻōnaehana endocrine a pili i ka neurotransmission a me ka hoʻonui ʻana o ka cell ma o ka launa pū ʻana me nā mea loaʻa somatostatin i hui pū ʻia me G-protein a ke kāohi nei i ka hoʻokuʻu ʻana o nā ʻano like ʻole. hormones.Nā hormones lua.Kāohi ʻo Somatostatin i ka huna ʻana o ka insulin a me ka glucagon.

Hele mai ʻo Somatostatin ma nā ʻano hana ʻelua, i hana ʻia e ka ʻoki ʻana o ka progenin hoʻokahi: ʻo kekahi he 14 amino acids (hōʻike ʻia ma ka pahu ʻike ma ka ʻākau), a ʻo kekahi he 28 amino acids.

I loko o nā vertebrates, aia nā ʻano genes somatostatin ʻokoʻa, i kapa ʻia ʻo SS1, SS2, SS3, SS4, SS5, a me SS6.Loaʻa iā Zebrafish nā ʻeono.ʻEono mau genes ʻokoʻa, me ʻelima mau mea loaʻa somatostatin ʻokoʻa, hāʻawi i ka somatostatin i kahi ākea o nā hana.Hoʻokahi wale nō gene somatostatin i ke kanaka, SST.

ʻōnaehana digestive
Hoʻopili ʻia ʻo Somatostatin e nā cell delta ma nā wahi he nui i ka ʻōnaehana digestive, ʻo ia hoʻi nā pyloric sinuses, duodenum, a me nā mokupuni.

ʻO ka Somatostatin i hoʻokuʻu ʻia e nā pyloric sinuses e komo i ka puʻuwai ma o ka ʻōnaehana puka a laila komo i ka ʻōnaehana systemic i kahi o ka inhibition.Eia hou, hiki i ka somatostatin i hoʻokuʻuʻia e nā pūnaewele δ ke hana ma keʻano paracrine.

I loko o ka ʻōpū, hana pololei ʻo somatostatin i nā ʻāpana parietal e hana ana i ka waikawa ma o nā mea hoʻokipa G-protein-coupled (e kāohi ana i ka cyclase adenylate a no laila e kūʻē maikaʻi ai i ka histamine stimulation) e hōʻemi i ka huna ʻana o ka ʻōpū.Hoʻolohi maikaʻi ʻo Somatostatin i ke kaʻina hana hoʻoheheʻe ma o ka hoʻohaʻahaʻa ʻole ʻana i ka hana ʻana o ka ʻōpū o ka ʻōpū ma ke kāohi ʻana i ka hoʻokuʻu ʻana o nā hormones ʻē aʻe e like me ka gastrin a me ka histamine.