Hiki ke mālama ʻia ka Clobetasol propionate i psoriasis?

Clobetasol propionatehiki ke mālama i ka psoriasis.

Nā huaʻōlelo like:

17-propionate;cgp9555;Clobetasol 17- propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Hoʻohana:

Clobetasol PropionateʻO ia ke ʻano paʻakai propionate o clobetasol, kahi corticosteroid synthetic topical me nā waiwai anti-inflammatory, anti-pruritic, a me nā waiwai vasoconstrictive.Hoʻohana ka Clobetasol propionate i kona hopena ma o ka hoʻopaʻa ʻana i nā mea hoʻokipa cytoplasmic glucocorticoid a ma hope o ka hoʻāla ʻana i ka glucocorticoid receptor mediated gene expression.ʻO kēia ka hopena i ka synthesis o kekahi mau protein anti-inflammatory, ʻoiai ke keʻakeʻa nei i ka synthesis o kekahi mau mea hoʻolaha inflammatory.Ma ke ʻano kikoʻī, ʻike ʻia ʻo clobetasol propionate e hoʻoulu i nā protein inhibitory phospholipase A2, a laila e kāohi ana i ka hoʻokuʻu ʻana o ka waika arachidonic inflammatory precursor mai nā phospholipid membrane e phospholipase A2.

ʻO Clobetasol propionate ka ester 17-O-propionate o clobetasol a loaʻa mai ia mai kahi clobetasol a me kahi waikawa propionic.He corticosteroid ikaika, hoʻohana ʻia e mālama i nā maʻi ʻili like ʻole, me ka exzema a me psoriasis.
Ua hoʻopaʻa ʻia ʻo Clobetasol propionate i ka makahiki 1968 a ua hoʻohana ʻia i ka lāʻau lapaʻau ma 1978. Loaʻa ia ma ke ʻano he lāʻau lapaʻau maʻamau.Hoʻohana ʻia ʻo Clobetasol propionate no ka mālama ʻana i nā maʻi ʻili like ʻole me ka eczema, herpes labialis, psoriasis, a me ka lichen sclerosus.Hoʻohana ʻia e mālama i kekahi mau maʻi auto-immune, me ka alopecia areata, lichen planus (auto immune skin nodules), a me mycosis fungoides (T-cell skin lymphoma).Hoʻohana ʻia ʻo ia e like me ka lāʻau lapaʻau mua no ka GVHD acute a me ka maʻi o ka ʻili. ʻO Clobetasol propionate (Cormax, Temovate, Embeline, Olux) kekahi o nā mea ikaika loa i loaʻa i kēia manawa a hōʻike ʻia no ka mālama pōkole o ka inflammatory. a i ʻole nā ​​maʻi hyperplastic.ʻO ia kahi corticosteroid fluorinated synthetic.Hiki iā ia ke hana i ka pane wikiwiki a lōʻihi paha ma mua o nā corticosteroids topical.Manaʻo ʻia e loaʻa ka clobetasol i ka 60 g i kēlā me kēia pule no ka lōʻihi o 14 mau lā me ka ʻole o ka hoʻopili ʻana a ʻaʻole pono e hoʻohana ʻia i nā keiki ma lalo o 12 makahiki.

ʻO kahi hopena o ka betamethasone 21-methanesulfonate (4 g) i ka dimethylformamide (25 ml) i mālama ʻia me ka lithium chloride (4 g) a me ka hui ʻana i wela ma ka ʻauʻau mahu no 30 mau minuke.ʻO ka hoʻoheheʻe ʻia me ka wai i hāʻawi ʻia i ka huahana ʻōpala i hana hou ʻia e loaʻa i ka hui inoa, MP 226°C.
Hoʻololi pinepine ʻia ʻo Clobetasol i ka propionate e like me ke ʻano kūpono ma o ka pane ʻana me propionic anhydride.