Glucagon CAS: 16941-32-5 Glucagon(1-29) Kanaka HCl GLUCAGON 1-37

ʻO Glucagon, ka mea i ʻike ʻia he hyperglycemin a me ka glucagon, he hormone polypeptide kaulahao pololei i huna ʻia e nā cell α o ka mokupuni pancreatic, nona nā waikawa amino 29.ʻO kāna kumu molekala a me kona kaumaha molekala pili he C153H225N43O49S=3482.8.Ua hana ʻia kēia hormone ma koʻu ʻāina.ʻO ka pauka kristal keʻokeʻo keʻokeʻo ma ka lumi wela, ʻaʻohe ʻala, ʻono ʻole.ʻAʻole hiki ke hoʻoheheʻe ʻia i loko o ka wai a me ka hapa nui o nā mea hoʻoheheʻe organik, hiki ke hoʻoheheʻe ʻia i loko o ka waikawa dilute a me ka lye dilute.Hana ʻia ka hapa nui o kāna hydrochloride, hiki ke hoʻoheheʻe ʻia i ka wai.Ua ʻike ʻia i kēia manawa pono e mālama ka glucagon i kona kūpaʻa molekala i mea e hoʻokō ai i kāna hana physiological.Hiki ke kūlike ke ʻano o ka hyperglycemic i loko o ke kanaka a me nā mammals (lapeti, pipi, puaʻa, ʻiole, etc.), akā ʻokoʻa iki i nā manu.He hormone koʻikoʻi ia e mālama ai i ke kō koko maʻamau.ʻO kāna hana nui ka hoʻoulu ʻana i ka phosphorylase i ka myocardium, hoʻoikaika i ka decomposition glycogen a loaʻa nā hopena like-catecholamin.No laila, he hopena koʻikoʻi ka puʻuwai ma ka puʻuwai, hoʻonui i ka puʻuwai puʻuwai, myocardial contractility a me ke kahe koko coronary.ʻAʻole i hui pū ʻia ka Cardioenhancement me ka hoʻonui ʻana i ka excitability cardiac, akā hoʻonui i nā ion calcium i loko o nā cardiomyocytes a hiki ke hoʻāla i ka adenosine cyclase ma ka membrane o ke akepaʻa ma Chemicalbook, e hāpai ana i ka synthesis o cyclic adenosine phosphate i loko o nā cell.Ua hōʻike ʻia ka maikaʻi o Glucagon i kekahi mau hihia o ka puʻuwai puʻuwai.Eia kekahi, ua hoʻonui pū ʻia nā pae plasma i nā pae like ʻole i ka maʻi maʻi, ka maʻi ate, ka maʻi kīkī, ka maʻi glucagon a me ke kaumaha.ʻEhā mau hana physiological ʻo Glucagon no ka hoʻolaha ʻana i ka glycogenolysis ate, glycogenogenesis ate, lipolysis a me ka hoʻokumu ʻana o ke kino ketone.Hiki iā ia ke hoʻoikaika i ka lawe ʻana o nā waikawa amino i loko o nā pūnaʻi ate, e hoʻolalelale i ke kaʻina hana deamination o nā waikawa amino i loko o ke akepaʻa, e hoʻemi i ka neʻe ʻana o nā waikawa amino i loko o ka plasma, e hoʻemi i ka synthesis protein a hoʻoikaika i ka glycogenogenesis ate.Eia kekahi, hiki iā ia ke hoʻoikaika i ka mana lipase o nā pūnaewele mālama lipid ate, hoʻonui i ka hoʻokuʻu ʻana i nā ʻakika momona manuahi, e hoʻolalelale i ke kaʻina hana o ka lipoic acid oxidation o nā pūpū ate, a hoʻonui i ka hana o ka ate glycoconeogenesis a me nā kino ketone.I ka manawa like, hiki i ka glucagon ke kāohi i ka ʻāʻī a me ka peristalsis o ka ʻōpū, ka ʻōpū liʻiliʻi a me ka kolone, e hoʻemi i ke ʻano o ka gallbladder, ke kāohi i ka exocrine pancreatic, a ke kāohi i ka absorption o ka wai a me ka paʻakai e ka mucosa intestinal.Hiki i ka nui o ka glucagon ke hoʻonui i ka manaʻo cAMP i loko o nā cell myocardial, hoʻonui i ka puʻuwai puʻuwai a hoʻonui i ka contractility myocardial.