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CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

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  • NO KA CAS:152685-85-3
  • inoa:HEMORPHIN-7
  • ʻO ke kumu hoʻohālikelike:C49H64N12O11
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  • pka:3.50±0.10(Wanamua)
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  • Huahana Huahana

    Huahana Huahana

    Hoʻohana

    ʻO LVV-hemorphin-7 (LVV-h7) he peptide bioactive i hopena mai ka hoʻohaʻahaʻa ʻana o ke kaulahao hemoglobin β-globin.ʻO LVV-h7 kahi agonist kūikawā no ka angiotensin IV receptor.No ka papa insulin-regulated aminopeptidase (IRAP) kēia mea hoʻokipa a he hana oxytocin.Maʻaneʻi, manaʻo mākou e loiloi: i) inā paha e hoʻololi ka LVV-h7 i ke ʻano o nā ʻiʻo i hoʻopaʻa ʻia a me ka pane ʻana o ka naʻau i ke kaumaha, a ii) ʻo ke kumu kumu o nā hopena LVV-h7 e pili ana i ka hoʻāla ʻana o ka oxytocin (OT) receptor, ʻo ia paha ka ka hopena o ka hoʻemi ʻana i ka hana proteolytic IRAP i ka wā o ka wā.Loaʻa i nā ʻiole Wistar kāne makua (270 -- 370 g) (ip) LVV-h7 (153 nmol/kg) a i ʻole ka mea lawe (0.1 ml).Ua hoʻohana ʻia nā kuʻuna like ʻole: i) Hoʻāʻo Open Field (OP) no nā hana haʻuki/ʻimi;ii) Elevated Cross mazes (EPMs) no ka hana e like me ka hopohopo;iii) Ho'āʻo hoʻāʻo ʻauʻau ikaika (FST) no ka ʻano like me ke kaumaha a me iv) hoʻoheheʻe ʻia i ka ea no ka pane ʻana i ka maʻi cardiovascular i ka ʻike ʻana i ke kaumaha.ʻO Diazepam (2 mg / kg) a me imipramine (15 mg / kg) i hoʻohanaʻia e like me nā mana maikaʻi no EPM a me FST.Ua hoʻohana ʻia nā antagonists OT receptor (OTr) atosiban (1 a me 0.1 mg / kg) e hoʻoholo ai i ke komo ʻana o ke ala oxytocin.Ua ʻike mākou ʻo LVV-h7: i) hoʻonui i ka helu o nā mea komo a me ka manawa i hoʻohana ʻia i ka maze me nā lima hāmama, e hōʻike ana i ka anti-anxiety;ii) Hoʻoulu i nā hopena antidepressant i nā hoʻokolohua FS;iii) Hoʻonui ʻia ka ʻimi ʻana a me ka neʻe ʻana;iv) ʻaʻole i hoʻololi i nā pane cardiovascular a me neuroendocrine i ke koʻikoʻi koʻikoʻi.Eia kekahi, ua hoʻihoʻi hou ʻia ka hoʻoikaika kino a me nā hopena antidepressant LVV-h7 e ka OTr antagonists.Hoʻoholo mākou ua hoʻololi ʻo LVV-h7 i ka ʻano i hōʻike ʻia ma kahi hapa e ka oxytocin receptor.

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