Vasoactive Intestinal Peptide CAS: 40077-57-4 VASOACTIVE PEPTIDE INTERESTINAL, PORCINE VASOACTIVE INESTINAL PEPTIDE

Vasoactive intestinal peptides, kuma aka sani da vasoactive intestinal peptides ko VIP, su ne peptide hormones da suke vasoactive a cikin gut.VIP peptide ne mai dauke da ragowar amino acid guda 28 wanda ke na glucagon/secretin superfamily kuma shine ligand na Class II G protein-couped receptors.Ana samar da VIP a cikin kyallen kashin baya da yawa, gami da hanji, pancreas, da kuma suprachiasmatic tsakiya na hypothalamus na kwakwalwa.VIP yana motsa tsokar zuciya, yana haifar da vasodilation, yana ƙara rushewar glycogen, yana rage hawan jini kuma yana shakatawa tsokoki masu santsi a cikin trachea, ciki da gallbladder.A cikin mutane, peptides na hanji mai vasoactive ana ɓoye su ta kwayoyin VIP.

Rabin rayuwar (t ½) na VIP a cikin jini kusan mintuna biyu ne.

VIP yana da tasiri akan ƙungiyoyi daban-daban:

A cikin tsarin narkewar abinci, VIP ya bayyana yana haifar da annashuwa na tsoka mai santsi (ƙananan sphincter na esophageal, ciki, gallbladder), yana motsa ruwa a cikin ruwan pancreatic da bile, kuma yana hana ɓoyewa da ɗaukar acid na ciki daga rami na hanji.Matsayinsa a cikin hanji shine tada hankali sosai na ruwa da electrolytes, haka kuma yana shakatar da tsoka mai santsi na hanji, fadada tasoshin jini, tada sigar bicarbonate ta pancreas da hana fitar da gastrin mai kuzari.Waɗannan tasirin suna aiki tare don haɓaka motsi.Yana kuma kara kuzarin fitar da pepsinogen ta babban tantanin halitta.VIP ya bayyana a matsayin muhimmin neuropeptide a lokacin cututtukan hanji mai kumburi saboda mast cell da VIP sadarwa an daidaita su a cikin colitis kamar cutar Crohn.

Har ila yau, yana cikin zuciya kuma yana da tasiri mai mahimmanci akan tsarin zuciya.Yana haifar da vasodilation na jijiyoyin jini kuma yana da tasirin inotropic da chronotropic tabbatacce.Ana ci gaba da bincike don sanin ko yana da tasiri mai amfani wajen magance ciwon zuciya.VIP yana motsa lubrition na farji a cikin mata na al'ada, yana ninka adadin yawan man da aka samar