SARM SR9011 Pharmaceutical Raw Foda Don Ƙarfafa Jimiri na Motsa jiki CAS 1379686-30-2
Takardar bayanai:SR9011
Bayani na 1379686-29-9
Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl) -N-pentylpyrrolidine-
1-carboxamide
Saukewa: C23H31ClN4O3S
Nauyin Molucelar 479.03524
Saukewa: SR9011Bayani
SR9011 trifunctional methacrylate monomer ne wanda ke ba da mannewa na musamman ga ƙarfe
substrates.
Ana ba da shawarar SR9011 don amfani a cikin rufin da aka warkar da peroxide, masu ɗaukar hoto, da plastisols na tushen PVC.
Ana ba da shawarar matakan amfani na 5% zuwa 10% ta nauyi.
SR9011 mai ƙarfi ne kuma takamaiman roba REV-ERB.Hakanan yana da kyau a cikin vivo plasma / bayyanar kwakwalwa.
Masu karɓar makaman nukiliya REV-ERB-a da REV-ERB-β suna taka muhimmiyar rawa wajen daidaita maganganun.
na core clock proteins, tuki rhythms a cikin aiki da kuma metabolism.Gudanar da SR9011 ya canza
Halin circadian da tsarin circadian na ainihin agogon kwayar halitta a cikin hypothalami na mice.
Alamar magana ta circadian na tsararrun kwayoyin halitta na rayuwa a cikin hanta, tsokar kwarangwal da
An kuma canza ƙwayar adipose, wanda ya haifar da ƙarin kashe kuɗi.Maganin cin abinci
beraye masu kiba tare da SR9011 sun rage kiba ta hanyar rage yawan kitse da ingantaccen dyslipidemia da hyperglycaemia.Waɗannan sakamakon suna nuna cewa haɗin gwiwar REV-ERB na roba waɗanda ke da alaƙa da magunguna
rhythm na circadian na iya zama da amfani a cikin maganin matsalolin barci da kuma cututtuka na rayuwa.
Yadda ake amfani da SR9011?
In vitro: An yi amfani da SR9011 a 5-10 μM maida hankali a cikin vitro da kuma a cikin salon salula.
A cikin vivo: Gudanar da IP na SR9011 an yi amfani dashi a 100 mg / kg sau ɗaya ko sau biyu a rana don 12-30
kwanaki a daban-daban linzamin kwamfuta model.
Bayani na SR9009 da SR9011
Abu | Ƙayyadaddun bayanai | Sakamako |
Bayyanar | Foda mara wari, kusan fari ko fari | wuce |
Identificaton | Lokacin riƙewa na babban kololuwa shine tabbata ga RS | wuce |
Asara akan bushewa | Ba fiye da 0.5% | 0.33% |
Assay (HPLC) | Ba kasa da 99.0% | 99.59% |
Ragowar wuta | Ba fiye da 0.1% | wuce |
Karfe mai nauyi | Ba fiye da 20 ppm ba | wuce |