Ci gaban Osteogenic Peptide-OGP CAS: 132996-61-3 OGP acetate CIGABAN OSTEOGENIC PEPTIDE USP/EP/BP

Somatostatin, wanda kuma aka sani da girma hormone suppressor hormone (GIH) ko wasu sunaye da yawa, shine hormone peptide wanda ke daidaita tsarin tsarin endocrin kuma yana rinjayar neurotransmission da yaduwar kwayar halitta ta hanyar yin hulɗa tare da masu karɓa na G-protein-coupled somatostatin da kuma hana sakin nau'i-nau'i iri-iri. hormones.Na biyu hormones.Somatostatin yana hana haɓakar insulin da glucagon.

Somatostatin yana zuwa ne ta nau'i biyu masu aiki, wanda aka samar ta hanyar canza yanayin yankan zuriya ɗaya: ɗaya wanda ya ƙunshi amino acid 14 (wanda aka nuna a cikin akwatin bayani a hannun dama), ɗayan kuma ya ƙunshi amino acid 28.

A cikin kashin baya, akwai kwayoyin halittar somatostatin daban-daban guda shida, masu suna SS1, SS2, SS3, SS4, SS5, da SS6.Zebrafish suna da duka shida.Halittu daban-daban guda shida, tare da masu karɓar somatostatin daban-daban guda biyar, suna ba somatostatin ayyuka da yawa.Mutane suna da kwayar somatostatin guda ɗaya kawai, SST.

tsarin narkewar abinci
Somatostatin yana ɓoye ta sel delta a wurare da yawa a cikin tsarin narkewa, wato pyloric sinuses, duodenum, da tsibirai.

Somatostatin da aka saki ta hanyar sinuses na pyloric yana shiga cikin zuciya ta hanyar hanyar tashar jiragen ruwa sannan kuma ya shiga cikin tsarin kewayawa zuwa wurin da aka hana.Bugu da ƙari, somatostatin da aka saki ta δ sel na iya aiki a cikin hanyar paracrine.

A cikin ciki, somatostatin yana aiki kai tsaye a kan ƙwayoyin parietal masu samar da acid ta hanyar G-protein-coupled receptors (wanda ke hana adenylate cyclase kuma don haka ya dace da haɓakar haɓakar histamine) don rage haɓakar acid na ciki.Somatostatin kuma yana rage aikin narkewar abinci yadda ya kamata ta hanyar rage samar da acid a cikin ciki a kaikaice ta hanyar toshe sakin wasu sinadarai kamar gastrin da histamine.