Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE
Amfani
Nonoreceptor / orphenkephalin FQ (N / OFQ) shine 17-amino acid neuropeptide wanda shine ligand na endogenous na nonoreceptor (ORL-1).Nociceptive peptide, a matsayin ingantaccen magani na maganin analgesic, zai iya magance tasirin maganin kashe zafi sosai.An haɗa kunna shi zuwa ayyukan kwakwalwa kamar fahimtar jin zafi da koyo na tsoro.
Lambar kwayoyin halittar prepronociceptin tana kan ɗan adam Ch8p21.An samo peptides masu jin zafi daga furotin peptide mai mahimmanci na propain, tare da wasu peptides guda biyu, nocistatin da NocII, dukansu suna hana aikin mai karɓar N / OFQ.Nociceptin shine misali na farko na baya-bayan magunguna;An gano mai karɓar NOP kafin gano ligands na endogenous ta ƙungiyoyi biyu daban-daban a cikin 1995.
A cikin nazarin dabba, an kuma gano hanyar N/OFQ-NOP mai karɓa don yin tasiri mai kyau da mara kyau a cikin ilmantarwa da ƙwaƙwalwa.Misali, raguwa a cikin wannan hanyar an danganta shi da sauye-sauyen koyon tsoro a cikin rikicewar kwakwalwa irin su rikicewar damuwa bayan tashin hankali (PTSD).Don haka, hanyoyin masu karɓa suna kula da martanin homeostasis ga tsoro da yanayi masu damuwa.Nociceptor kuma na iya taka rawar hanawa a cikin aikin ƙwaƙwalwar ajiya, kamar yadda wasu binciken suka nuna cewa yana lalata ilimin sararin samaniya a cikin vivo yayin da yake hana haɓakawa na dogon lokaci da watsa synaptic a cikin vitro.
