JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

JWH-018 (1-pentyl-3- (1-naphthoyl) indole, NA-PIMO ko AM-678) wani sinadaran analgesic ne a cikin dangin naphthoyl indole, wanda aka bayyana a cikin CB 1 da CB 2 cannabinoid masu karɓa, Yana da wasu selectivity for CB 2. Yana samar da sakamako a cikin dabbobi kama da THC, wani cannabinoid samu ta halitta a cannabis, kai ga yin amfani da roba cannabis kayayyakin, wanda a wasu ƙasashe ana sayar da doka a matsayin "ƙamshi blends."

A matsayin cikakken agonist ga CB 1 da CB 2 cannabinoid masu karɓa, wannan fili an rarraba shi azaman analgesic.Sakamakon analgesic na cannabinoid ligands wanda masu karɓa na CB1 suka yi amfani da su sun kasance da kyau a cikin maganin ciwon neuropathic, ciwon daji, da arthritis.

Wadannan mahadi suna aiki ta hanyar kwaikwayi kwayoyin halittar endocannabinoid na jiki, irin su 2-AG da anandamide (AEA), waɗanda ke aiki da ilimin halitta kuma suna iya haɓaka ko hana siginar jijiya.Saboda an san kadan game da abubuwan da ke haifar da jihohi masu ciwo na kullum, dole ne a gudanar da bincike da ci gaba da yawa kafin a iya samun damar maganin warkewa na irin waɗannan kwayoyin halitta.