Glucagon CAS: 16941-32-5 Glucagon(1-29) Human HCl GLUCAGON 1-37

Glucagon, wanda kuma aka sani da hyperglycemin da glucagon, sigar madaidaiciyar sarkar polypeptide hormone ne wanda sel α na tsibirin pancreatic ke ɓoye, yana ɗauke da amino acid 29.Tsarin kwayoyinsa da nauyin kwayoyin dangi shine C153H225N43O49S=3482.8.An haɗa wannan hormone a cikin ƙasata.Farin lu'u-lu'u mai kyau a zafin jiki, mara wari, mara daɗi.Mai narkewa a cikin ruwa da mafi yawan kaushi na halitta, mai narkewa a cikin dilute acid da dilute lye.Yawancin shirye-shiryen ana yin su ne da hydrochloride, wanda ke narkewa cikin ruwa.Yanzu an san cewa glucagon dole ne ya kiyaye amincin kwayoyin halittarsa ​​don aiwatar da aikin ilimin halittarsa.Tsarin hyperglycemic na iya zama daidai a cikin mutane da dabbobi masu shayarwa (zoma, shanu, alade, beraye, da sauransu), amma ɗan bambanta a cikin tsuntsaye.Yana da mahimmancin hormone don kula da sukarin jini na al'ada.Babban aikinsa shine kunna phosphorylase a cikin myocardium, inganta bazuwar glycogen kuma yana da tasirin catecholamin.Saboda haka, yana da tasiri mai karfi na zuciya a kan zuciya, yana ƙara yawan zuciya, ƙwaƙwalwar zuciya da jini na jini.Cardioenhancement ba ya tare da ƙãra zuciya excitability, amma ƙara alli ions a cikin cardiomyocytes kuma iya kunna adenosine cyclase a kan hanta cell membrane a cikin Chemicalbook, inganta kira na cyclic adenosine phosphate a cikin sel.An ba da rahoton Glucagon yana da tasiri a wasu lokuta na gazawar zuciya.Bugu da ƙari, matakan plasma kuma sun karu zuwa nau'i daban-daban a cikin ciwon sukari, cututtukan hanta, cututtukan koda, ƙwayar glucagon da damuwa.Glucagon yana da ayyuka na ilimin lissafi guda huɗu na haɓaka hanta glycogenolysis, hanta glycogenogenesis, lipolysis da samuwar jikin ketone.Yana iya haɓaka haɓakar amino acid a cikin ƙwayoyin hanta, haɓaka tsarin deamination na amino acid a cikin hanta, rage ƙaddamar da amino acid a cikin plasma, rage haɓakar furotin da haɓaka hanta glycogenogenesis.Bugu da ƙari, yana iya kunna ƙarfin lipase na sel ajiya na lipid hanta, haɓaka sakin fatty acids kyauta, haɓaka tsarin oxidation na lipoic acid na ƙwayoyin hanta, da haɓaka haɓakar hanta glycoconeogenesis da jikin ketone.A lokaci guda, glucagon na iya hana tashin hankali da peristalsis na ciki, ƙananan hanji da hanji, rage tashin hankali na gallbladder, hana exocrine pancreatic, da hana sha ruwa da gishiri ta hanji mucosa.Yawancin allurai na glucagon kuma na iya ƙara haɓakar CAMP a cikin ƙwayoyin myocardial, ƙara yawan bugun zuciya da haɓaka haɓakar ƙwayar zuciya.