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Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide

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  • Sunan gama gari:Exendin-4
  • Lambar CAS:141758-74-9
  • Tsarin kwayoyin halitta:Saukewa: C184H282N50O60S
  • Nauyin kwayoyin halitta:4186.57188
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    Siffa:

    Sunan gama gari Exenatide Sunan Ingilishi Exenatide acetate gishiri
    Lambar CAS 141758-74-9
    Tsarin kwayoyin halitta Saukewa: C184H282N50O60S
    Nauyin kwayoyin halitta 4186.57000
    Madaidaicin taro 4184.03000
    PSA 1775.05000
    Yanayin ajiya An rufe, adana a -20ºC
    Kwanciyar hankali Babu rubewa, babu sanannen halayen haɗari idan an yi amfani da su kuma an adana su bisa ga ƙayyadaddun bayanai

     

    Amfani:

    Exenatide shine magani na farko a cikin sabon nau'in masu ciwon sukari da aka sani da incretin mimetics, kuma ana nuna shi azaman ƙarin magani don haɓaka sarrafa glycemic a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 waɗanda ke shan metformin, sulfonylurea, ko duka biyun, amma ba su da. samu isasshen sarrafa glycemic.Exenatide analog ne mai aiki na ɗan adam incretin Glucagon-Kamar Peptide-1 (GLP-1).GLP-1 ana fitar da shi ta dabi'a daga sel a cikin sashin GI don mayar da martani ga ci abinci kuma yana aiki akan mai karɓar sa akan ƙwayoyin b don haɓaka haɓakar insulin mai motsa glucose.Exenatide agonist ne na dogon lokaci a mai karɓar GLP-1.Sigar roba ce ta peptide 39-amino acid da ake samu a cikin sinadarai na salivary na gila monster lizard.haka kuma yana daidaita matakan glucagon kololuwa yayin lokutan hyperglycemic bayan cin abinci, amma baya tsoma baki tare da sakin glucagon don amsa hypoglycemia.Tsarin dosing don exenatide shine 5 ko 10 MG sau biyu a rana, ana gudanar da shi azaman allurar subcutaneous a cikin awa ɗaya kafin abinci na safe da maraice.Bayan gudanar da aikin subcutaneous, mafi girman adadin exenatide na plasma ya kai cikin sa'o'i 2.1, kuma bayanin martabar pharmacokinetic na plasma ya yi daidai da kashi.Mafi yawan abubuwan da suka fi dacewa da cutar da aka ruwaito tare da exenatide sun hada da tashin zuciya, amai, zawo, jittery, dizziness, ciwon kai, da dyspepsia.

    Exendin-4 na iya kunna mai karɓar GLP-1, mai karɓa zai iya ƙara yawan matakan CAMP na ƙwayoyin acinar pancreatic a cikin salula, amma ba shi da wani tasiri a kan mai karɓar VIP.

    An yi amfani da Exendin-4 azaman incretin mimetics don magani a cikin ƙwayoyin HepG2 don ware tasirin kayan taimako.Hakanan an yi amfani dashi azaman r (GLP-1R) agonist don ware tsangwama daga kayan taimako.

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