Sarm S4 Andarine Yellow foda
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Andarine (S-4) shine arylpropionamide-wanda aka samu fili [S-3- (4-acetylamino-phenoxy) -2-hydroxy-2-methyl-N- (4-nitro-3-trifluoromethyl-phenyl) -propionamide] na farko. Yin et al ya bayyana.don zama mai zaɓin mai karɓar mai karɓar mai karɓa na androgen (SARM).Andarine (S-4) an nuna shi ta in vitro da kuma nazarin vivo don zama agonist anabolic mai tasiri, ba tare da sakamako na gefe ba sau da yawa hade da anabolic-androgenic steroids, wanda ke da alaka da mahimmanci don ƙaddamar da dangantaka don 5a-reductase don samar da DHT a cikin prostate.
Ayyukan pharmacological na andarine suna ba da shawarar babban yuwuwar andarine a cikin haɓakar SARMs na asibiti, wanda ke ba da fa'idodin warkewa na musamman akan takwarorinsu na steroidal da dama mai ban sha'awa don bambanta tasirin androgen a cikin kyallen takarda daban-daban, don haka rage tsangwama ga al'ada. .Don haka, andarine yana da alƙawarin a cikin gwaje-gwaje na asibiti na ci gaba wanda ke nufin magance cututtukan da suka shafi shekaru da kuma magance alamun cututtuka masu tsanani irin su sarcopenia da ciwon daji cachexia.
Andarine zaɓaɓɓen mai karɓar mai karɓar isrogen mai karɓar isrogen (AR) ne tare da Ki na 4 nM.Andarine yana nuna aikin anabolic mai ƙarfi da inganci kuma yana haifar da haɓakar dogaro da kashi na girma a cikin prostate, vesicles na seminal, bi da bi.Andarine yana da tasirin antiosteoporotic.
Andarine (wanda aka fi sani da GTx-007; S-4; GTx007; S4) wani agonist ne na baka da kuma zabar wadanda ba steroidal androgen receptor (AR) agonist, musamman zabin androgen receptor modulator (SARM), wanda ke da yuwuwar amfani ga ɓata tsoka. da kuma osteoporosis.Yana kunna AR tare da Ki na 4 nM kuma shine zaɓi na nama don gabobin anabolic.Ana binciken Andarine don magance yanayi kamar ɓarnawar tsoka, osteoporosis da hypertrophy na prostatic mara kyau.A cikin samfurin dabba na hypertrophy na prostate benign, an nuna andarine don rage nauyin prostate tare da irin wannan tasiri ga finasteride, amma ba tare da samar da wani raguwa a cikin ƙwayar tsoka ba ko magungunan anti-androgenic.
Ƙayyadaddun bayanai
gama gari | Farashin S4 | Sunan Ingilishi | Andarine |
Lambar CAS | 401900-40-1 | nauyin kwayoyin halitta | 441.358 |
yawa | 1.5± 0.1 g/cm3 | wurin tafasa | 698.7± 55.0 °C a 760 mmHg |
tsarin kwayoyin halitta | C 19 H 18 F 3 N 3 O 6 | wurin narkewa | 70-74ºC |
PSA | 133.48000 | Ma'anar walƙiya | 376.4± 31.5 °C |
LogP | 4.01 | tururi matsa lamba | 0.0± 2.3 mmHg a 25 ° C |