Prostaglandins Chemical Product 99% tsarki API Material Lumigan Bimatoprost CAS 155206-00-1 don magance ido
Tuntube ni:
Email:ceo66@hbainuodi.com
Whtasapp:+8618849057872
Saukewa: 868
Amfani
Bimatoprost magani ne na prostaglandin wanda aka fara amfani dashi don magance cututtukan ido kamar glaucoma.Sunan maganin Lumigan.Duk da haka, a lokacin jiyya, mai haƙuri ba zato ba tsammani ya gano cewa diamita, tsayi da yawa na gashin ido ya karu sosai.Bayan haka, an yi amfani da bimatoprost a gwaji na asibiti don kyawun gashin ido.Babban tasirin sa akan kauri da kauri kai tsaye ya kai ga ƙaddamar da Lattise ta kamfanin samar da Lumegen, Allergan.An ƙaddamar da maganin a cikin Disamba 2008. Hukumar FDA ta Amurka ta amince da shi, ya zama samfurin ƙwararru don yin baƙar fata da kauri.
A cikin Yuli 2006, bimatoprost-timolol maleate fili fili na ido drops wanda United States Allergan Co., Ltd. ta amince da shi daga ikon magungunan EU don rage martani ga masu amfani da β-receptor blockers ko prostaglandins.Matsin intraocular ko hauhawar jini na ido a cikin marasa lafiya tare da glaucoma mai buɗewa waɗanda ba su amsa da kyau ga maganin analog.Magungunan ido na ido sun ƙunshi 0.0Chemicalbook3% bimatoprost da 0.5% timolol maleate, sau ɗaya a rana, yana iya samar da tasirin kula da matsa lamba na intraocular na asibiti sosai, kuma tasirin ya fi na bimatoprost kadai.Matoprost ko timolol maleate.Gwaje-gwaje na asibiti sun tabbatar da cewa miyagun ƙwayoyi yana da kyakkyawar jurewa, ciki har da raguwa 40% a cikin abin da ya faru na hyperemia na ido idan aka kwatanta da bimatoprost kadai.
Don maganin glaucoma, ana iya amfani dashi a cikin ruwa mai girma gashin ido, maida hankali shine 0.03%
Ƙayyadaddun bayanai
| Sunan samfur | Bimatoprost |
| CAS | 155206-00-1 |
| Yawan yawa | 1.1 ± 0.1 g/cm3 |
| Wurin tafasa | 629.8 ± 55.0 ° C AT 760 mmHg |
| Wurin narkewa | 66-68 ° C |
| Kwayoyin halitta | Saukewa: C25H37NO4 |
| Nauyin kwayoyin halitta | 415.566 |
| Ma'anar walƙiya | 334.7 ± 31.5 ° C |
| Madaidaicin inganci | 415.272247 |
| PSA | 89.79000 |
| Shiga | 1.98 |
| Bayyanar | Crystal Solid |
| Turi matsa lamba | 0.0 ± 1.9 mmHg AT 25 ° C |
| Indexididdigar refractive | 1.591 |
| Yanayin ajiya | 20 ° C |
Wasu Bimatoprost CAS 155206-00-1 Bincike:
Olaparib yana da tasiri akan ciwan nono Brca1; p53 (50mg/kg alluran intraperitoneal kowace rana), amma ba shi da wani tasiri a kan Ecad-rashin HR; p53 ciwan nono.Olaparib ba shi da cutar da ke iyakance kashi a cikin berayen da ke ɗauke da ƙari.An yi amfani da Olaparib don magance ciwace-ciwacen daji tare da maye gurbi na BRCA, kamar ciwon daji na ovarian, ciwon nono, da ciwon prostate.Bugu da kari, Olaparib ya hana ATM-rashin ciwace-ciwacen ƙwayoyin cuta zaɓe, yana nuna cewa za a iya amfani da Olaparib a matsayin wakili mai yuwuwa don maganin ciwace-ciwacen ƙwayoyin cuta na ATM.
Olaparib shine mai hanawa na PARP wanda kuma yayi aiki da maye gurbin BRCA1 ko BRCA2.Olaparib yana da ɗan tasiri akan tanky (polymer) enzyme-1, kuma ƙimar IC50 ya fi haka girma.Olaparib a matakin 30-100nM yana aiki akan sel SW620 don kunna PARP-1.Layukan tantanin halitta na BRCA1 (MDA-MB-463 [1] da HCC1937) suna da hankali ga Olaparib idan aka kwatanta da BRCA1- da BRCA2-isasshen layin salula (Hs578T, MDA-MB-23,T47D) Olaparib yana hana PARP kuma yana toshe Gyara Gyaran tushe. , yana haifar da ƙarfin hankali na ƙwayoyin KB2P zuwa Olaparib.Sakamako shine jujjuyawar karya guda ɗaya zuwa hutun madauri biyu yayin kwafin DNA, don haka kunna hanyar sake haɗawa ta BRCA2.
Bimatoprost wani nau'in prostamide F2a ne na roba, wanda zai iya zaɓin daidaita tasirin prostamine a cikin jiki, haɓaka ƙimar samar da jin daɗin ruwa, rage juriya na fitowar ɗanɗano ruwa, da haɓaka tashar hanyar sadarwa ta trabecular da uveal sclera Ana la'akari da shi. zama maganin glaucoma na gida tare da tasiri mafi ƙarfi akan rage matsa lamba na intraocular.Ya dace da maganin glaucoma buɗaɗɗen kusurwa (POAG) ko babban gani wanda ba shi da tasiri tare da wasu magungunan rage matsa lamba na intraocular.Masu cutar hawan jini (OHT).
An lura:
Idan kuna sha'awar, da fatan za a tuntuɓe mu kyauta, za mu ba da amsa cikin lokaci. Fatan mu sami haɗin kai.