Chemical samfurin Bromazolam CAS 71368-80-4
Bayanan asali
Tsarin kwayoyin halitta: C17H13BrN4
- Matsayin narkewa: 272.0-275 ℃
- Matsayin tafasa: 519.8 ± 60.0 ° C (An annabta)
- yawa: 1.54± 0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37± 0.40 (an annabta)
- Tsarin kwayoyin halitta: C17H13BrN4
- Nauyin Kwayoyin: 353.21600
- Daidai Mass: 352.03200
- Saukewa: 43.07000
- Shafin: 3.12480
Amfani
An rarraba Bromazolam azaman sabon benzodiazepine wanda aka fara haɗa shi a cikin 1976, amma ba a taɓa yin kasuwa ba.Daga baya an sayar da shi azaman magani mai ƙira, wanda EMCDDA ta fara gano ta a Sweden a cikin 2016. Shi ne bromo maimakon chloro analogue na alprazolam, kuma yana da irin wannan maganin kwantar da hankali da tasirin anxiolytic.Bromazolam yayi kama da benzodiazepines na gargajiya, gami da alprazolam (maye gurbin chlorine da bromine) da bromazepam (ƙarin zoben triazole).Alprazolam da bromazepam sune Jadawalin abubuwa na IV a cikin Amurka;bromazolam ba a tsara shi a fili ba.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine ana amfani da shi don nazarin aikin antianxiety, antidepressant da psychotropics don tsarin kulawa na tsakiya.
Hanyar Shiri
An bi da su tare da pHLS9 (2 mg protein / ml), 25 μg/mL Alamethicin (UGT reaction mix B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, da 0.6 mM a 37 ° C NADP +, 0.9 U/ml isocitrate dehydrogenase, 100 U/mL superoxide dismutase da 0.1 mM acetyl-CoA.Sa'an nan, 2.5 mM UDP-glucuronic acid (UGT reaction cakuda bayani A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, da 50 μM clobromazolam ko Bromazolam.
Yanayin Amsa:50 μM Bromazolam na 360min a cikin 37 ° C
Aikace-aikace:Bromazolam metabolites sun kasanceganoa cikin pHLS9 incubation.