China Hot Sale CAS 2160555-52-0 5CAKB48 cannabinoids white power

Chemistry

5F-AKB48, or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide, is a synthetic indazolecarboxamide as it contains a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22. Additionally, the indazole is substituted at R3with a carboxamide group. This carboxamide group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. 5F-AKB48 is an analog of STS-135 in which the core indole structure is substituted with an indazole base.

Physical effects

Spontaneous physical sensations

The "body high" of 5F-AKB48 can be described as a sharp, uncomfortable, all-encompassing, and electric tingling sensation that spreads over the body after initial ingestion. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.

Motor control loss -

This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose, but rarely results in a complete inability to walk and perform basic movements.

Appetite enhancement 

As with many other cannabinoids, 5F-AKB48 causes an increase in appetite, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food. This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.

Pain relief 

Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB₁ and CB₂, which extends to synthetic cannabinoid receptor agonists.

Perception of bodily lightness

Changes in gravity

Dehydration

This is known colloquially as "cotton mouth" in popular American and United Kingdom culture.

Vasodilation