Chemical API Powder Benzos CAS 146-22-5 Nitrazepam (CRM)

short description:

CAS NO: 146-22-5

Name: Nitrazepam

Chemical formula: C15H11N3O3

MW: 281.27

EINECS: 205-665-2

Melting point: 223-227℃

Boiling point: 423.94°C (rough estimate)

density : 1.2309 (rough estimate)

form: neat

refractive index: 1.5700 (estimate)

Fp : 2℃

storage temp.: Controlled Substance, -20°C Freezer

solubility : Practically insoluble in water, slightly soluble in ethanol (96 per cent).

pKa: 2.90 ± 0.05;10.39±0.04(H2O,t =25,I=0.015(KCl))(Approximate)

Water Solubility : 3.93mg/L(25 ºC)

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Usage

Benzodiazepine: Hypnotic

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NOx. See also DIAZEPAM.

Drug interactions

Potentially hazardous interactions with other drugs

Antibacterials: metabolism possibly increased by rifampicin.

Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine.

Antivirals: concentration possibly increased by ritonavir.

Disulfiram: metabolism of nitrazepam inhibited, increased sedative effects.

Sodium oxybate: enhanced effects of sodium oxybate - avoid

Metabolism Metabolised in the liver, mainly by nitroreduction followed by acetylation; none of the metabolites possess significant activity. Excreted in the urine mainly as metabolites.