Beta-Neoendorphin CAS: 77739-21-0 YS-TYR-PRO-OH YGGFLRKYP

β-neoendorphin is an endogenous opioid peptide with a nine-peptide structure and amino acid sequence of Tyr-Gly-Gly-Phe - Leu-Arg-Lys-Tyr-Pro (YGGFLRKYP).

Beta-neoendorphins (beta-nep) have the ability to stimulate wound healing by accelerating keratinocyte migration. This is achieved by beta-Nep activation of mitogen activated protein kinase (MAPK) and extracellular signal-regulated kinases 1 and 2 (ERK 1 and ERK 2); And upregulation of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). Wound healing of β-NEP leads to migration without affecting the proliferation of human keratinocytes